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Login united states global austria brasil china denmark france germany italy japan korea 홈 norway portugal south africa spain sweden switzerland taiwan united kingdom worldwide extranets careers site map united states laboratories health care providers patients allergens news media about us start > health care providers > autoimmunity > diseases > liver diseases > primary biliary cirrhosis about autoimmunity diseases connective tissue diseases rheumatoid arthritis antiphospholipid syndrome vasculits and anti-gbm associated diseases celiac disease/other gastrointestinal diseases thyroid diseases liver diseases autoimmune hepatatis primary biliary cirrhosis miscellaneous characteristics of phadia tests decision points partnerships case studies document library resources services links text size + - primary biliary cirrhosis primary biliary cirrhosis (pbc) is a chronic disease of unknown cause, affecting women as much as 10 to 20 times as frequently as men and is perhaps the only autoimmune disease never reported in children; its incidence gradually rises with age. It is characterized by chronic intrahepatic cholestasis due to chronic inflammation and necrosis of intrahepatic bile ducts and progresses insidiously to biliary cirrhosis. generic viagra canada Its prevalence has been estimated to be 2. 3-14. viagra no prescription pharmacy 4 per 100,000. viagra 100mg how long The histologic abnormalities in the liver have been divided into four stages. The earliest changes (stage i) are most specific and consist of localized areas of infiltration of intrahepatic bile ducts with lymphocytes and necrosis of biliary epithelial cells. viagra coupon In stage ii there is proliferation of bile ductules, prominent infiltration of portal areas with lymphoid cells, and early portal fibrosis. Stage ii is characterized by reduction of the inflammatory changes, paucity of bile ducts in the portal triads, and increased portal fibrosis. In stage iv, fibrosis is prominent in biliary cirrhosis and a marked increase in hepatic copper is found. generic viagra online Thus, the pathologic process is characterized by slowly progressive, spotty destruction of bile ducts, with associated inflammation and fibrosis and, ultimately, cirrhosis. â© 2011 thermo fisher scientific inc. All rights reserved. buy viagra online All trademarks are the property of thermo fisher scientific inc. And its subsidiaries. Legal manufacturer: phadia ab, uppsala, sweden. Contact privacy policy legal notice site map. buy viagra cheap Ice (cd search) e-utilities prosplign protein clusters protein database reference sequence (refseq) all proteins resources... Sequence analysis blast (basic local alignment search tool) blas. what is generic viagra safe buy viagra
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